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Data Digests

Stay current with concise, clinically relevant synopses of key data from clinical research and real-world studies. Digests highlight key findings, clinical implications, and areas for ongoing investigation. 

Effect of Antidepressant Switching vs Augmentation on Remission Among Patients With Major Depressive Disorder Unresponsive to Antidepressant Treatment: The VAST-D Randomized Clinical Trial
Data Digests

Effect of Antidepressant Switching vs Augmentation on Remission Among Patients With Major Depressive Disorder Unresponsive to Antidepressant Treatment: The VAST-D Randomized Clinical Trial

This randomized clinical trial investigated the relative effectiveness and safety of three common treatment approaches for major depressive disorder (MDD) in patients who did not adequately respond to their initial antidepressant treatment. The study aimed to assess the effects of three next-step treatment strategies, including switching to a norepinephrine/dopamine-reuptake inhibitor (NDRI), augmenting with an NDRI, or augmenting with an atypical antipsychotic.

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